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Melanoma is a killer and is common here in Arizona where we get so many days of intense sunlight.  By now everyone should know the drill:  Keep out of the midday sun whenever possible; Use sunscreen; Watch for changes in moles; See a dermatologist regularly for skin exams.  For many of us, however, the lessons about prevention may come too late.   We spent long hours in the sun and got some bad sunburns when we were kids.  For those who develop melanoma despite precautions or because of long-ago exposure, there is good news on the horizon.

Scientists and research physicians are developing new treatments for dealing with melanoma.  For example, researchers at the Mayo Clinic are working on a treatment which uses a modified rabies virus to deliver altered DNA to melanoma tumors.  Once they have absorbed the altered DNA, the tumors can no longer hide from the host body’s immune system.  The treatment has been very effective in mice and has completely eliminated melanoma tumors in many of them.

Other researchers are engaged in testing drugs on actual patients with advanced melanoma which has already spread to the brain.  One of the drugs has shown great promise in shrinking brain tumors and lengthening the life of the patients who receive it.  Another group is testing an inhibitor which has proved to be very effective on those melanomas which have a particular gene mutation.  This is another example of the promise of gene-based therapies.  Rather than try a medication on everyone in the hopes that a few will benefit, in the future doctors will be able to identify in advance the patients who are most likely to be helped by a particular medication and direct it only to them.

As promising as these advances are, they are not here yet and it is important to continue to take the steps necessary to reduce your risk of melanoma.  At least as important, however, is the need to remain vigilant.  Watch your skin for changes.  Go see a dermatologist promptly if you notice suspicious changes.  At least when it comes to your skin, change is bad.

Posted in:
Cancer, Doctors, Melanoma

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